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Coronavirus – Are the Numbers of Cases Reliable?

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Right now, we are being told that the novel coronavirus that causes the Covid-19 disease is such an existential threat to all of us that we need extreme measures to deal with it.  More than half the world’s population is bunkered down at home under effective house arrest; a form of medical martial law prevails of the streets; most “nonessential” shops and businesses are closed; and trust and social contact between people has almost completely broken down.  So is the threat from the new disease worthy of these unprecedented consequences?

Let’s take a close look at the figures.  A good source of official data which is updated regularly is the Worldometers Coronavirus page..  The latest figures here as of the time of writing (25th April 2020) are shown by the following summary snapshot from the site:

So, at this time we have more than two and a quarter million cases and more than 150,000 deaths.  That sounds pretty bad, right?  But we can only put this into context if we compare with the numbers for deaths and cases from other, broadly similar diseases and, for deaths, by comparing with global death rates as a whole.

I will return to the subject of death rates later, but firstly let’s concentrate on case numbers: how are these numbers being calculated?  We hear a lot about testing of suspected cases, but what do we know about these tests?

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The first thing to note is that, perhaps contrary to popular belief, there is not one standard test being used around the world to test for coronavirus infection; each country is more or less using its own methodology.

Also, as I have discussed in a previous post, tests are not a magic 100% reliable indicator of whether someone has a disease or not.  Some of them are really quite unreliable indeed.  It’s actually quite a technical challenge to make accurate tests for common diseases, particular those caused by viruses.  If it were that easy, the shops would be full of such test kits.  Do you not think there would be a huge market for a simple, accurate home test for, say, the flu?  And the market would undoubtedly be much bigger for home tests for embarrassing viral diseases such as herpes and sexually transmitted infections.

And even if it were possible to manufacture a fairly accurate test for a disease, if the disease you are testing for is uncommon (as is currently the case with Covid-19 despite all the media hype to the contrary) then the rate of false positives this test will give you will be really high.  I will go into more detail on this later to illustrate that the world is largely suffering from a pandemic of false positives for Covid-19 rather than of the disease itself.

The general approach to testing for Covid-19 can be gauged from the US Centre for Disease Control’s (CDC’s) web pages on testing  and their information for laboratories doing Covid-19 testing.  So, let’s take a look at the two main types of testing that are being done for Covid-19 around the world right now: polymerase chain reaction (PCR) based tests and serology/antibody-based tests.

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PCR Based Tests

Many SARS-CoV-2 tests are based on what is called “Reverse Transcription Polymerase Chain Reaction” or RT-PCR.  This is a type of more general process called the polymerase chain reaction (PCR).  Wikipedia gives good general explanations of the principles of PCR testing as a whole, as well as the type of RT-PCR tests used for Covid-19 testing.

Without going into too many technical details here, the general idea of a PCR test is to take a sample from a patient and multiply up all the target DNA in the sample (using the polymerase chain reaction, PCR).  The target DNA sequence used is designed to try and uniquely identify the target virus or bacteria so that if this sequence is found you can be reasonably sure you have found the target organism.

Serology/Antibody Based Tests

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Given all the problems with PCR based testing, some companies and countries are investigating the use of antibody-based tests instead.  The idea here is to try and detect antibodies – proteins produced by the body to fight infection – against the SARS-CoV-2 virus in the blood or other bodily fluids of a patient. The UK is working on getting antibody tests available in bulk for their population.  The CDC in the US is also looking at developing such tests.

I won’t discuss these kinds of tests in so much detail because most countries including our own Ghana and health care systems are still mainly reliant on RT-PCR based testing.  This is partly because accurate antibody tests are not widely available, being both difficult and time consuming to prepare in great numbers.  But suffice to say that antibody tests, even when they have been successfully manufactured, are also subject to many problems too.

BY RISK OFORIWAA DAUDA

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Ghana becoming a developed nation

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In a country like ours in which we are aware of our challenges, all that is required is focusing on strengthening our institutional processes by making them more robust and transparent. In this regard, investment in digitilisation must be prioritised since the human element to cut corners is inherent in the psyche of some people and therefore cannot be trusted to do the right things out of their own volition.

Enforcement of existing laws and regulations must be reviewed to see what is working, which ones have to be tweaked to be able to address current challenges, and those that have become obsolete and must be discarded.

One issue that needs to be given priority attention is remuneration. A former President is alleged to declare that we pretend to pay workers and they also pretend to work. This indeed sums up the quandary facing government after government. Workers’ salaries are crucial in the fight against corruption. A realistic living wage must be given to workers; otherwise, they will seek avenues to address their personal budget deficit.

On day one, what should engage the attention of government is Energy, making it available and affordable. The industrialisation agenda cannot be successfully executed without power that is readily available, reliable, and affordable. Solar energy must be factored in the quest for affordable and reliable power for industry.

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The fuel sector issues must be urgently addressed so that it can impact positively on the transportation sector, which plays a key role in the supply of goods and services. The railway infrastructure plan linking places like Boankra Inland Port to prolong the lifespan of our roads and to fast track distribution of goods from the Capital City to the inland areas of the country should be a top priority item.

A well-structured system linking industry to academia must be quickly established to serve as a catalyst towards the industrialisation drive. Research findings from the universities must be channelled to captains of industry in a timely manner. Effective channels of communication should be established to facilitate shorter product-to-market times.

An effective mechanism for fishing out needy but talented children must be established, as well as a sponsorship package for talented individuals who are needed for certain critical areas of the economy — what I term critical investment in education.

Certain changes must be made in the constitution, particularly the appointment of the heads of certain constitutional bodies or institutions. This is to ensure that the Executive arm of government does not wield too much power to ensure accountability and checks and balances really work.

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The Attorney General’s Office must be detached from the Executive arm of government. The Nolle Prosequi provision must also be amended to compel the Attorney General to give an explanation of why he or she is declining to prosecute a particular case or discontinue it. The provision that protects sitting Presidents from prosecution must also be reviewed.

The punishment for some of our laws needs a review. We must review the removal of CJ provision to ensure the independence of the Judiciary.

Above all, there must be a mindset of change, i.e., a paradigm shift from inability to capability. Inferiority complex must give way to a pacesetters mentality, and all will be well. God bless.

NB: KOTOKA INTERNATIONAL AIRPORT TO KOFI BAAKO INTERNATIONAL AIRPORT

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BY LAUD KISSI-MENSAH

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The impact of emotional surgery and emotional elysium on neurological and neurosurgical procedures

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Abstract
THIS comprehensive review aims to explore the impact of emotional surgery and emotional elysium on neurological and neurosurgical procedures. We examine the scientific literature on these approaches, including their definitions, theoretical frameworks, and applications. Our analysis highlights the potential benefits and risks of these approaches and discusses their implications for practice.


Introduction

Neurological and neurosurgical procedures are complex and delicate, requiring precision and accuracy to achieve optimal outcomes. Emotional surgery and emotional elysium are two innovative approaches that have the potential to enhance the success of these procedures. Emotional surgery involves the use of art and other creative techniques to promote relaxation and reduce stress, while emotional elysium focuses on cultivating positive emotions and promoting emotional well-being.


The Role of Emotional Surgery in Neurological and Neurosurgical Procedures

Emotional surgery has been shown to be effective in reducing anxiety and stress in patients undergoing neurological and neurosurgical procedures. By promoting relaxation and reducing stress, emotional surgery can help patients prepare for procedures, leading to improved outcomes and faster recovery times.


The Role of Emotional Elysium in Neurological and Neurosurgical Procedures

Emotional elysium has been shown to be effective in promoting emotional balance and resilience in patients undergoing neurological and neurosurgical procedures. By cultivating positive emotions and promoting emotional well-being, emotional elysium can help patients cope with the stress and trauma associated with these procedures, leading to improved outcomes and enhanced quality of life.

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Benefits of Emotional Surgery and Emotional Elysium

The benefits of emotional surgery and emotional elysium in neurological and neurosurgical procedures are numerous. These approaches can:

  • Reduce anxiety and stress: Emotional surgery and emotional elysium can help patients manage anxiety and stress, leading to improved outcomes and faster recovery times.
  • Improve emotional regulation: Emotional surgery and emotional elysium can help patients regulate their emotions, leading to improved mental health and well-being.
  • Enhance patient experience: Emotional surgery and emotional elysium can improve the patient experience, leading to increased satisfaction and improved outcomes.

Conclusion

In conclusion, emotional surgery and emotional elysium are two innovative approaches that have the potential to enhance the success of neurological and neurosurgical procedures. By reducing anxiety and stress, promoting emotional balance and resilience, and improving patient experience, these approaches can lead to improved outcomes and enhanced quality of life for patients undergoing these procedures.


Recommendations

  • Further research is needed: More research is needed to fully understand the benefits and risks of emotional surgery and emotional elysium in neurological and neurosurgical procedures.
  • Integration into practice: Emotional surgery and emotional elysium should be considered for integration into practice, as they may offer a valuable tool in the treatment of a range of neurological and neurosurgical conditions.

By exploring innovative approaches like emotional surgery and emotional elysium, we can improve patient outcomes and enhance the quality of life for individuals undergoing neurological and neurosurgical procedures.

BY ROBERT EKOW GRIMMOND-THOMPSON

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