What booze can do to you

Ethanol, the chemical compound present in most alcoholic drinks, is a neurotoxin, that is, a sub­stance that can damage or destroy the nervous system. Someone who is drunk is, in fact, suffering from a form of poisoning.

In large quantities, ethanol caus­es coma and death. For instance, among students in Japan, the prac­tice of ‘ikkinomi, or alcohol chug­ging, causes deaths every year.

The body is able to convert eth­anol into harmless substances, but this is not accomplished immediate­ly. If alcohol is consumed at a faster rate than the body can handle, ethanol builds up in the system and begins to interfere noticeably with brain function. In what way?

Speech, vision, coordination, thought, and behaviour are all connected with an incredibly com­plex series of chemical reactions in the brains neurons, or key cells. The presence of ethanol modifies those reactions, suppressing or enhancing the role of certain neutrontransmit­ters chemicals that relay signals from neuron to neuron.

The stream of information in the brain is thus altered, preventing the brain from functioning normally. That is why when a person drinks too much, he or she develops slurred speech, blurred vision, sluggish movement, and weakened be­havioural restraints and inhibitions, all common symptoms of intoxica­tion.

EXPOSURE

With prolonged exposure to alcohol, brain chemistry adapts to counter the poisonous effect of eth­anol and to maintain normal nerve function. This leads to tolerance, whereby the same amount of alcohol has less of an effect than it would have had previously.

Dependence occurs when the brain has adapted so much to the presence of alcohol that it cannot operate properly without it. The body craves alcohol to maintain the chemical balance.

When a person is deprived of alcohol, his brain chemistry is totally destabilised and withdrawal symp­toms, such as anxiety, trembling, or even seizures, set in.

Besides causing modifications of brain chemistry, alcohol abuse can lead to cell atrophy and destruction, altering the brain’s very structure. While partial recovery is possible with abstinence, some of this damage seems to be irreversible.

Neurons that die are apparently never replaced, further affecting memory and other cognitive func­tions.

Damage to the brain is not just the result of long term exposure to alcohol.

Research seems to indicate that even relatively short periods of alco­hol abuse can be harmful.

LIVER DISEASE

AND CANCER

The liver plays a vital role in me­tabolising food, combating infection, regulating blood flow and removing toxic substances, including alcohol, from the body.

Prolonged exposure to alcohol damages the liver in three stages. During the first state, the breaking down of ethanol slows the digestion of fats, causing them to build up in the liver.

This is called steatohepatitis, or fatty liver. In time, chronic inflam­mation of the liver, or hepatitis, sets in. While alcohol can cause hepatitis directly, it also appears to lower the body’s resistance to Hepatitis B and Hepatitis C viruses.

If unchecked, inflammation causes cells to burst and die. Compounding this damage, alcohol seems to trigger the natural system of programmed cells death called apoptosis.

This final stage is cirrhosis. The vicious cycle of continuous inflamma­tion and cell destruction causes irre­versible scarring. Eventually, the liver becomes humpy, instead of remaining spongy.

Finally, scar tissue prevents blood from flowing normally, leading to liver failure and death.

Alcohol’s effect on the liver has another insidious side effect -the liver is less capable of playing its defensive role in counteracting the effect of cancer-forming agents.

In addition to favouring the devel­opment of cancer of the liver, alcohol greatly increases the risk of cancer of the mouth, the pharynx, the larynx, and the oesophagus.

What is more, alcohol makes the mucous membranes in the mouth more easily penetrated by cancerous substances in tobacco, elevating the risk for smokers.

Women who drink daily are at greater risk of breast cancer. Accord­ing to one study, the risk for those who drank three or more alcoholic beverages per day was 69 per cent higher than that of nondrinkers.

POISONED BABIES

A particularly tragic outcome of alcohol abuse is its effect on the unborn. “Alcohol is far worse for the developing fetus than any other abused drug,” reported by the ‘Inter­national Herald Tribune.’

When a pregnant woman drinks, her developing chin also drinks and the toxic effect of alcohol is espe­cial, devastating at this format stage of the fetus.

Alcohol causes irreversible damage to its central nervous system. Neurons do not form properly. Cells are killed off. Other cells end up located in the wrong place.

The result, fetal alcohol syndrome (FAS), is the foremost cause of mental retardation in newborns. Difficulties encountered by FAS children include intellectual impairment, language problems, developmental delay, be­havioural dysfunction or deficit, slow growth, hyper activity, and hearing and sight disorders. Many babies are also born with characteristic facial deformities.-Credit: AWAKE

This article was first published on Saturday, November 5, 2005